Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277), Biota orientalis extracts or NSAIDs for the treatment of dogs with osteoarthritis associated pain: a blinded, placebo-controlled study

Introduction: With little to no regulation of the supplement markets and a paucity of quality information regarding clinical utility of individual marketed supplements, it is difficult for veterinarians to provide any evidence-based recommendations to owners. The current study aimed to provide clinically useful comparative efficacy data on certain marketed supplements.

Methods: Using a prospective, block-randomized, double-blinded, placebo-controlled design, one hundred and one pet dogs with clinical hip OA-associated pain with one side worse than the other (index limb) were randomly assigned to one of four treatment groups: Green lipped Mussel plus Krill oil extracts (Antinol® Rapid, EAB-277); Biota orientalis extracts (4CYTE™ Epiitalis® Forte); an NSAID (meloxicam); or placebo (sunflower oil). Peak vertical force (PVF, expressed as a percentage of bodyweight) of the index limb, orthopedic assessment score (OAS) and hematology and blood chemistry values were evaluated before treatment (week 0), at 2, 4 and 6 weeks during treatment.

Results: At 6 weeks, the changes from baseline in PVF of the index limb in the EAB-277 and meloxicam groups were significantly greater than the change in the placebo and 4CYTE™ groups, and the placebo and 4CYTE groups were not different from each other. At 6 weeks, there were significant differences between the groups for overall OAS scores with the lowest scores (least impairment) in the EAB-277 and meloxicam groups, followed by the 4CYTE group and then the placebo group.

Discussion: Results of this study indicate that meloxicam and EAB-277 have significant objectively measured benefits in managing OA-related pain in dogs compared to placebo, but 4CYTE does not differ from placebo.

TYPE Original Research

PUBLISHED 10 October 2024

DOI 10.3389/fvets.2024.1464549

OPEN ACCESS

EDITED BY

Luca Pennasilico, University of Camerino, Italy

REVIEWED BY

Ronald Jan Corbee, Utrecht University, Netherlands

Maxim Moreau, Montreal University, Canada

*CORRESPONDENCE

B. Duncan X. Lascelles dxlascel@ncsu.edu

RECEIVED 14 July 2024

ACCEPTED 17 September 2024

PUBLISHED 10 October 2024

CITATION

Kampa N, Kaenkangploo D, Jitpean S, Srithunyarat T, Seesupa S, Hoisang S, Yongvanit K, Kamlangchai P, Tuchpramuk P and Lascelles BDX (2024) Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277), Biota orientalis extracts or NSAIDs for the treatment of dogs with osteoarthritis associated pain: a blinded, placebo-controlled study.

Front. Vet. Sci. 11:1464549.

doi: 10.3389/fvets.2024.1464549

COPYRIGHT

© 2024 Kampa, Kaenkangploo, Jitpean, Srithunyarat, Seesupa, Hoisang, Yongvanit, Kamlangchai, Tuchpramuk and Lascelles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Kampa et al. 10.3389/fvets.2024.1464549 Frontiers in Veterinary Science 02 frontiersin.org

KEYWORDS

OA, marine based fatty acid, omega 3, NSAID, gait analysis, PVF