Treatment of Severe Hind Limb Paresis and Posterior Paresis Caused by Traumatic Myelopathy in Cats Using PSCO-524® (Antinol®) and Physical Therapy

A 2 years old domestic short hair cat weighted 3.55 kilograms was referred to Kasetsart University Veterinary Hospital for severe hind limb paresis with loss of sensory function. The onset of symptoms was observed a week ago after the cat returned from missing. Radiographic examination did not show any vertebral disorders. Magnetic Resonance Imaging (MRI) examination found accumulation of fluid in spinal cord at T10-T12 level, which indicated spinal cord injury. Traumatic myelopathy was diagnosed.

The paresis was grade 5 so PSCO-524® (Antinol®) 1 capsule per day was prescribed. After a week of the treatment, the cat was able to control urination and voluntary motor function of the hind limbs.

However, the sensory system malfunction remained. Spinal walk, walking with the hind limbs when sensation loss was observed after physical therapy was concurrently provided for 3 weeks.

 

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Dog

A 18-month-old male intact chihuahua presented with recurrent neck pain within 3 months after stop using prednisolone.

Upon physical and neurological examination, dog displayed pain and neck stiffness without neurological deficits. Radiographic findings of cervical spine was normal.

The dog was treated with prednisolone to relieve pain and inflammation and showed improvement of clinical signs. However, the recurrence occurred in 7 months with more severity. Magnetic resonance

imaging (MRI) demonstrated Chiari-like malformation and syringomyelia at C2-C4 and C7-T1 region.

PCSO-524® (VetzPetz Antinol®) was administered in combination with prednisolone and gabapentin. The clinical signs improved in 2 weeks so prednisolone was gradually reduced until discontinued but dose of PCSO-524® remained constantly. The dog was able to recover from neck pain and continued life activities as normal.

Long-term supplement of PCSO-524® (VetzPetz Antinol®) was effective for reducing inflammation of spinal cord in dog suffered from neck pain caused by syringomyelia.

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A 3 years old domestic short hair cat had shown behavioral disorder after castration 4 months ago.

The clinical signs were consistent with obsessive-compulsive disorders (OCD).

Pathological examination found edema of epidermis andinfiltration of mature mast cells in hair follicle. Treatment with PCSO-524® (Antinol)® for 180 days had shown that the misbehavior was improved due to decreased pain and skin inflammation. Healthier coat and skin appearance was noticed after 30 consecutive days of PCSO-524® (Antinol®) intake. Pathological follow-up showed less inflammation of epidermis and decreased mast cells infiltration.

It was shown that PCSO-524® (Antinol®) could reduce pain and inflammation that caused anxiety and consequently OCD in cats. Additional effects included antihistamine, antiallergy, and skin neurishing.

 

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Male Shih tzu dog aged 9 years and 1 month was diagnosed with limb paralysis after jumping 4 days prior to the hospital visit.

The dog showed weak response of forelimb reflex and severe neck pain. X-ray examination showed block vertebrae at C3 and C4.

Magnetic resonance imaging (MRI) examination found mild disc protrusion, compression on spinal cord and myelopathy at C4 and C5 with compression on the right dorsal lamina.

Prednisolone and gabapentin were prescribed to reduce inflammation and pain, respectively.

Follow-up after reduction of prednisolone showed that the dog fell more often while walking and slight neck pain was present. Prednisolone dosage was then increased and PCSO-524® was prescribed to reduce inflammation of the spinal cord. Later examination found that the dog could walk without falling, both forelimbs showed normal reflex, and signs of neck pain disappeared. Termination of prednisolone was then started without any recurrent clinical signs.

 

After continuous treatment with PCSO-524® for 6 weeks, the dog could walk normally, both forelimbs showed normal reflex, and the ALK level was nearly back to the level prior to the treatment.

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Updated Study Topics

New researches and publications related to PCSO-524® and its result in clnical test submitted by veterinarians on the global conferences every year and the data keeps growing with more studies conducted

 

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