PCSO-524® Reference
1. Dugas B. Lyprinol inhibits LTB4 production by human monocytes. Allerg Immunol, 2000. 32(7): p. 284-289.
2. McPhee S, Hodges LD, Wright PFA, Wynne PM, Kalafatis N, Harney DW, et al. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B: Biochem Mol Biol, 2007. 146(3): p. 346-356.
3. Lee CH, Butt YKC, Wong MS, Lo SCL. A lipid extract of Perna canaliculus affects the expression of pro-inflammatory cytokines in a rat adjuvant-induced arthritis model. Eur Ann Allergy Clin Immunol, 2008. 40(4): p. 148-153.
4. Singh M, Hodges LD, Wright PFA, Cheah DMY, Wynne PM, Kalafatis N, et al. The CO2-SFE crude lipid extract and the free fatty acid
extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats. Comp Biochem Physiol B: Biochem Mol Biol, 2008. 149(2): p. 251-258.
5. Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broadbent J. Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 1997. 5(3): p. 237-246.
6. Treschow AP, Hodges LD, Wright PFA, Wynne PM, Kalafatis N, Macrides TA. Novel anti-inflammatory n-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B: Biochem Mol Biol, 2007. 147(4): p. 645-656.
7. Wolyniak CJ, Brenna JT, Murphy KJ, Sinclair AJ. Gas chromatography-chemical ionization-mass spectrometric fatty acid analysis of a commercial supercritical carbon dioxide lipid extract from New Zealand green-lipped mussel (Perna canaliculus). Lipids, 2005. 40(4):p. 355-360.
8. McPhee S, Kalafatis N, Wright P, Macrides T, (eds). The marine oil Lyprinol®, is a substrate for the 5-lipoxygenase enzyme in porcine neutrophils. in Proc Aust Soc Clin Exp Pharmacol Toxicol, 2001. 9: 95.
9. Whitehouse M, Roberts M, Brooks P. Over the counter (OTC) oral remedies for arthritis and rheumatism: How effective are they? Inflammopharmacology, 1999. 7(2): p. 89-105.
10. Rialland P, Bichot S, Lussier B, Moreau M, Beaudry F, del Castillo JRE, et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res, 2013. 77(1): p. 66-74.
11. Kwananocha I, Vijarnsorn M, Kashemsant N, Lekcharoensuk C. Effectiveness of disease modifying osteoarthritis agents and carprofen for treatment of canine osteoarthritis. Thai J Vet Med, 2016. 46(3): p. 363-371.
12. Soontornvipart K, Mongkhon N, Nganvongpanit K, Kongtawelert P. Effect of PCSO-524 on OA biomarkers and weight-bearing properties in canine shoulder and coxofemeral osteoarthritis. Thai J Vet Med, 2015. 45(2): p. 157-165.
13. Sundaravibhata K, Mongkhon N, Meahasab P. Application of the polyunsaturated fatty acid compound PCSO-524 in the postoperative recovery of dogs that have had stifle surgery. WSAVA 38th Ann Cong. Auckland, New Zealand 2013.
14. Sekar S, Crawford R, Xiao Y, Prasadam I. Dietary fats and osteoarthritis: Insights, evidences, and new horizons. J Cell Biochem, 2017.118(3): p. 453-463.
15. Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr, 2012. 107 Suppl 2: p. S171-S184.
16. Bacchi S, Palumba P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review. Antiinflamm Antiallergy Agents Med Chem, 2012. 11(1): p. 52-64.
17. Lascelles BD, McFarland JM, Swann H. Guidelines for safe and effective use of NSAIDs in dogs. Vet Therap, 2005. 6(3): p. 237-51.
18. Whitehouse MW, Butters DE. Combination anti-inflammatory therapy: Synergism in rats of NSAIDs/corticosteroids with some herbal/animal products. Inflammopharmacology, 2003. 11(4-6): p. 453-464.
19. Mongkon N, Soontornvipart K. Preliminary study of the clinical outcome of using PCSO-524 polyunsaturated fatty acid compound in the treatment of canine osteoarthritis and degenerative spinal diseases. Thai J Vet Med, 2012. 42(3): p. 311-317.
20. Kongwut S, Soontornvipart K, Sarikaphuti M, Makoom P, Nganvongpanit K. Effects of serum IL-1beta of PCSO-524 and Firocoxib in dogs undergoing medial patellar luxation repair. Thai J Vet Med, 2015. 45(4): p. 639-643.
21. Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 2011. 117(14): p. 3720-3732.
22. van Dalen SC, Blom AB, Slöetjes AW, Helsen MM, Roth J, Vogl T, et al. Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis. Osteoarthritis Cartilage, 2017. 25(3): p. 385-396.
23. Jamikorn U, Yibchok-anun S. Effects of dietary polyunsaturated fatty acid supplement on healthy Beagle dogs. Thai J Vet Med, 2014.44(4): p. 505-511.
24. Szechinski J, Zawadzki M. Measurement of pain relief resulting from the administration of Perna canaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of knee and/or hip joints. Rheumatologia, 2011. 49(4): p. 244-252.
25. Zawadzki M, Janosch C, Szechinski J. Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. Mar Drugs, 2013. 11(6): p. 1920-1935.
26. Cho SH, Jung YB, Seong SC, Park HB, Byun KY, Lee DC, et al. Clinical efficacy and safety of Lyprinol, a patented extract from New
Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: A multicenter 2-month clinical trial. Eur Ann Allergy Clin Immunol, 2003. 35(6): p. 212-216.
27. Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: A randomized trial. Complement Ther Med, 1998. 6(3): p. 122-126.
28. Puente R, Illnait J, Mas R, Mendoza S, Carbajal D, Fernández J, et al. Effects of D-002, a mixture of beeswax alcohols, co-administered with green-lipped mussel extract, on osteoarthritis symptoms. Int J Pharm Sci Rev Res, 2014. 27(1): p. 209-216.
29. Lau CS, Chiu PKY, Chu EMY, Cheng IYW, Tang WM, Man RYK, et al. Treatment of knee osteoarthritis with Lyprinol, a lipid extract of the green-lipped mussel: A double-blind placebo-controlled study. Prog Nutr, 2004. 6(1): p. 17-31.
30. Audeval B, Bouchacourt P. Double-blind trial against placebo of extract of Perna canaliculus (green-lipped mussel) in osteoarthritis of the knee. Gaz Med Fr, 1986. 93: p. 111-116.
31. Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner, 1980. 224: p. 955-960.
32. Gandek B. Measurement properties of the Western Ontario and McMaster Universities Osteoarthritis Index: A systematic review. Arthritis Care Res, 2015. 67(2): p. 216-229.
33. Lau CS, Chiu PKY, Chu EMY, Cheng IYW, Tang WM, Man RYK, et al. Treatment of knee osteoarthritis with Lyprinol, a lipid extract of the green-lipped mussel: A double-blind placebo-controlled study. Prog Nutr, 2004. 6(1): p. 17-31.
34. Lee CH, Butt YKC, Wong MS, Lo SCL. Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis. Inflammopharmacology, 2008. 16(4): p. 188-194.
35. Lee C-H, Lum JH-K, Ng CK-C, McKay J, Butt YK-C, Wong M-S, et al. Pain controlling and cytokine-regulating effects of Lyprinol, a lipid extract of Perna canaliculus, in a rat adjuvant-induced arthritis model. Evid Based Complement Alternat Med, 2009. 6(2): p. 239-245.
36. Wakimoto T, Kondo H, Nii H, Kimura K, Egami Y, Oka Y, et al. Furan fatty acid as an anti-inflammatory component from the greenlipped mussel Perna canaliculus. Proc Natl Acad Sci, 2011. 108(42): p. 17533-17537.
37. Pearson W, Orth MW, Karrow NA, Maclusky NJ, Lindinger MI. Anti-inflammatory and chondroprotective effects of nutraceuticals from Sasha’s Blend in a cartilage explant model of inflammation. Mol Nutr Food Res, 2007. 51(8): p. 1020-1030.
38. Yanez JA, Remsberg CM, Vega-Villa KR, Miranda ND, Navas J, Ohgami Y, et al. Pharmacological evaluation of Glyco-Flex® III and its constituents on canine chondrocytes. J Med Sci, 2008. 8: p. 98-101.
39. Beale S. Brian, Vijarnsorn Monchanok, Kawananocha Irin, Necas Alois, Lascelles X. B.Duncan. The Effectiveness of Marine Based Fatty Acid compound (PCSO-524) Alone and Combined with Firocoxib in the treatment of Canine Osteoarthritis. Veterinary Orthopaedic Society Conference. March 2018.
40. Vijarnson Monchanok, Kwananocha Irin, Kashemsant Naruedee, Jarudecha Thitichai, et al. Effectiveness of Marine Based Fatty Acid compound (PCSO-524) and Firocoxib in the treatment of Canine Osteoarthritis.BMC Veterinary Research 2019 OCT 17;15(1):349
41. Kwananocha Irin. Journal of Thai Veterinary Practitioners. 2020 (Synopsis)
42. Rungnirundon Teerapat, Senarut Napaporn. PCSO-524 (Antinol®) Use in Fighting Cocks for Treatment of Chronic Pododermatitis. Journal of Thai Veterinary Practitioners.2020 (Synopsis)
43. Nishida Koji.PCSO-524 Report Clinical Results of Nineteen Dogs with Tracheal Collapse that received PCSO-524,a Lipid Extract of New Zealand Green Lipped Mussel(Perna canaliculus). Journal of Modern Veterinary Medicine (MVM) Vol.24 No.163 (2016)
44. Tanrattana Chaiyot, Panitarnangit Sivavatchr, Moolasatsathorn Warawadee.Clinical Study of PCSO-524 (Antinol) as neutraceutical in Canine allergic skin disease. World Veterinary Association Congress 2018
_________________________________
EAB-277® Reference
1. Franklin SP, Park RD, Egger EL. Metacarpophalangeal and metatarsophalangeal osteoarthritis in 49 dogs. J Am Anim Hosp Assoc. (2009) 45:112–7. doi: 10.5326/0450112
2. Rychel JK. Diagnosis and treatment of osteoarthritis. Top Companion Anim Med. (2010) 25:20–5. doi: 10.1053/j.tcam.2009.10.005
3. Johnston SA. Osteoarthritis. Joint anatomy, physiology, and pathobiology. Vet Clin North Am Small Anim Pract. (1997) 27:699–723. doi: 10.1016/S0195-5616(97)50076-3
4. Wright A, Amodie DM, Cernicchiaro N, Lascelles BDX, Pavlock AM, Roberts C, et al. Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests. J Small Anim Pract. (2022) 63:609–18. doi: 10.1111/jsap.13500
5. Moreau M, Dupuis J, Bonneau NH, Desnoyers M. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Vet Rec. (2003) 152:323–9. doi: 10.1136/vr.152.11.323
6. Sanderson RO, Beata C, Flipo RM, Genevois JP, Macias C, Tacke S, et al. Systematic review of the management of canine osteoarthritis. Vet Rec. (2009) 164:418– 24.doi: 10.1136/vr.164.14.418
7. Edamura K, King JN, Seewald W, Sakakibara N, Okumura M. Comparison of oral robenacoxib and carprofen for the treatment of osteoarthritis in dogs: a randomized clinical trial. J Vet Med Sci. (2012) 74:1121–31. doi: 10.1292/jvms.11-0529
8. Vasseur PB, Johnson AL, Budsberg SC, Lincoln JD, Toombs JP, Whitehair JG, et al. Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal antiinflammatory drug, in the treatment of osteoarthritis in dogs. J Am Vet Med Assoc. (1995) 206:807–11.
9. Mansa S, Palmer E, Grondahl C, Lonaas L, Nyman G. Long-term treatment with carprofen of 805 dogs with osteoarthritis. Vet Rec. (2007) 160:427–30. doi: 10.1136/vr.160.13.427
10. Brown DC, Boston RC, Coyne JC, Farrar JT. Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis. J Am Vet Med Assoc. (2008) 233:1278–83. doi: 10.2460/javma.233.8.127
11. Bhathal A, Spryszak M, Louizos C, Frankel G. Glucosamine and chondroitin use in canines for osteoarthritis: a review. Open Vet J. (2017) 7:36–49. doi: 10.4314/ovj.v7i1.6
12. Monteiro-Steagall BP, Steagall PV, Lascelles BD. Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs. J Vet Intern Med. (2013) 27:1011–9. doi: 10.1111/jvim.12127
13. Aragon CL, Hofmeister EH, Budsberg SC. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J Am Vet Med Assoc. (2007) 230:514– 21. doi:10.2460/javma.230.4.514
14. Beale BS. Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Am Small Anim Pract. (2004) 34:271–89, viii. doi: 10.1016/j.cvsm.2003.09.008
15. McCarthy G, O’Donovan J, Jones B, McAllister H, Seed M, Mooney C. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. (2007) 174:54– 61. doi: 10.1016/j.tvjl.2006.02.015
16. Gupta RC, Canerdy TD, Lindley J, Konemann M, Minniear J, Carroll BA, et al. Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. J Anim Physiol Anim Nutr. (2012) 96:770–7. doi: 10.1111/j.1439-0396.2011.01166.x
17. Scott RM, Evans R, Conzemius MG. Efficacy of an oral nutraceutical for the treatment of canine osteoarthritis. A double-blind, randomized, placebocontrolled prospective clinical trial. Vet Comp Orthop Traumatol. (2017) 30:318– 23. doi: 10.3415/VCOT-17-02-0020
18. Fernandez-Martin S, Gonzalez-Cantalapiedra A, Munoz F, Garcia-Gonzalez M, Permuy M, Lopez-Pena M. Glucosamine and chondroitin sulfate: is there any scientific evidence for their effectiveness as disease-modifying drugs in knee osteoarthritis preclinical studies?-A systematic review from 2000 to 2021. Animals. (2021) 11:1608. doi: 10.3390/ani11061608
19. Mongkon N, Soontornvipart K. Preliminary study of the clinical outcome of using PCSO-524 polyunsaturated fatty acid compound in the treatment of canine osteoarthritis and degenerative spinal diseases. Thai J Vet Med. (2012) 42:311–7.
20. Soontornvipart K, Mongkhon N, Nganvongpanit K, Kongtawelert P. Effect of PCSO-524 on OA biomarkers and weight-bearing properties in canine shoulder and coxofemeral osteoarthritis. Thai J Vet Med. (2015) 45:157–65.
21. Kwananocha I, Vijarnsorn M, Kashemsant N, Lekcharoensuk C. Effectiveness of disease modifying osteoarthritis agents and carprofen for treatment of canine osteoarthritis. Thai J Vet Med. (2016) 46:363–71
22. Vijarnsorn M, Kwananocha I, Kashemsant N, Jarudecha T, Lekcharoensuk C, Beale B, et al. The effectiveness of marine based fatty acid compound (PCSO524) and firocoxib in the treatment of canine osteoarthritis. BMC Vet Res. (2019) 15:349. doi: 10.1186/s12917-019-2110-7
23. Suzuki Y, Fukushima M, Sakuraba K, Sawaki K, Sekigawa K. Krill oil improves mild knee joint pain: a randomized control trial. PLoS ONE. (2016) 11:e0162769. doi: 10.1371/journal.pone.0162769
24. Laflamme DP. Development and validation of a body condition score system for dogs. Canine Pract. (1997) 22:10–5.
25. Chow SC, Shao J, Wang H. Sample Size Calculations in Clinical Research, 2nd ed. Boca Raton, FL: Chapman and Hall/CRC (2003). doi: 10.1201/9780203911341
26. Hercock CA, Pinchbeck G, Giejda A, Clegg PD, Innes JF. Validation of a clientbased clinical metrology instrument for the evaluation of canine elbow osteoarthritis. J Small Anim Pract. (2009) 50:266–71. doi: 10.1111/j.1748-5827.2009.00765.x
27. Hielm-Bjorkman AK, Rita H, Tulamo RM. Psychometric testing of the Helsinki chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis. Am J Vet Res. (2009) 70:727– 34. doi: 10.2460/ajvr.70.6.727
28. Brown DC, Boston RC, Farrar JT. Comparison of force plate gait analysis and owner assessment of pain using the Canine Brief Pain Inventory in dogs with osteoarthritis. J Vet Intern Med. (2013) 27:22–30. doi: 10.1111/jvim.12004
29. Moreau M, Lussier B, Ballaz L, Troncy E. Kinetic measurements of gait for osteoarthritis research in dogs and cats. Can Vet J. (2014) 55:1057–65.
30. Waxman AS, Robinson DA, Evans RB, Hulse DA, Innes JF, Conzemius MG. Relationship between objective and subjective assessment of limb function in normal dogs with an experimentally induced lameness. Vet Surg. (2008) 37:241– 6. doi: 10.1111/j.1532-950X.2008.00372.x
31. McLaughlin RM. Kinetic and kinematic gait analysis in dogs. Vet Clin North Am Small Anim Pract. (2001) 31:193–201. doi: 10.1016/S0195-5616(01)50045-5
32. Conzemius MG, Torres BT, Muir P, Evans R, Krotscheck U, Budsberg S. Best practices for measuring and reporting ground reaction forces in dogs. Vet Surg. (2022) 51:385–96. doi: 10.1111/vsu.13772
33. Conzemius MG, Evans RB. Caregiver placebo effect for dogs with lameness from osteoarthritis. J Am Vet Med Assoc. (2012) 241:1314–9. doi: 10.2460/javma.241.10.1314
34. Venator KP, Frye CW, Gamble LJ, Wakshlag JJ. Assessment of a single intraarticular stifle injection of pure platelet rich plasma on symmetry indices in dogs with unilateral or bilateral stifle osteoarthritis from long-term medically managed cranial cruciate ligament disease. Vet Med. (2020) 11:31–8. doi: 10.2147/VMRR.S238598
35. Chervier, C.; Cadore, J.L.; Rodriguez-Pineiro, M.I.; Deputte, B.L.; Chabanne, L. Causes of anaemia other than acute blood loss and their clinical significance in dogs. J. Small Anim. Pract. 2012, 53, 223–227. [Google Scholar] [CrossRef] [PubMed]
36. Borchert, C.; Herman, A.; Roth, M.; Brooks, A.C.; Friedenberg, S.G. RNA sequencing of whole blood in dogs with primary immune-mediated hemolytic anemia (IMHA) reveals novel insights into disease pathogenesis. PLoS ONE 2020, 15, e0240975. [Google Scholar] [CrossRef]
37. Balch, A.; Mackin, A. Canine immune-mediated hemolytic anemia: Pathophysiology, clinical signs, and diagnosis. Compend. Contin. Educ. Vet. 2007, 29, 217–225. [Google Scholar] [PubMed]
38. Morley, P.; Mathes, M.; Guth, A.; Dow, S. Anti-erythrocyte antibodies and disease associations in anemic and nonanemic dogs. J. Vet. Intern. Med. 2008, 22, 886–892. [Google Scholar] [CrossRef] [PubMed]
39. Kjelgaard-Hansen, M.; Goggs, R.; Wiinberg, B.; Chan, D.L. Use of serum concentrations of interleukin-18 and monocyte chemoattractant protein-1 as prognostic indicators in primary immune-mediated hemolytic anemia in dogs. J. Vet. Intern. Med. 2011, 25, 76–82. [Google Scholar] [CrossRef] [PubMed]
40. Cuq, B.; Blois, S.L.; Bedard, C.; Wood, R.D.; Abrams-Ogg, A.C.; Beauchamp, G.; Wood, G.A. Serum interleukin 17 concentrations in dogs with immune-mediated hemolytic anemia. J. Vet. Intern. Med. 2021, 35, 217–225. [Google Scholar] [CrossRef]
41. Archer, T.M.; Mulligan, C.; Narayanan, L.; Riggs, C.; Fellman, C.; Thomason, J.M.; Wills, R.W.; Boothe, D.M.; Cruz-Espindola, C.; Harmon, R.; et al. Effects of oral administration of 5 immunosuppressive agents on activated T-cell cytokine expression in healthy dogs. J. Vet. Intern. Med. 2020, 34, 1206–1213. [Google Scholar] [CrossRef][Green Version]
42. Swann, J.W.; Skelly, B.J. Systematic review of evidence relating to the treatment of immune-mediated hemolytic anemia in dogs. J. Vet. Intern. Med. 2013, 27, 1–9. [Google Scholar] [CrossRef]
43. Swann, J.W.; Skelly, B.J. Evaluation of immunosuppressive regimens for immune-mediated haemolytic anaemia: A retrospective study of 42 dogs. J. Small Anim. Pract. 2011, 52, 353–358. [Google Scholar] [CrossRef]
44. Swann, J.W.; Garden, O.A.; Fellman, C.L.; Glanemann, B.; Goggs, R.; LeVine, D.N.; Mackin, A.J.; Whitley, N.T. ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs. J. Vet. Intern. Med. 2019, 33, 1141–1172. [Google Scholar] [CrossRef][Green Version]
45. Wolyniak, C.J.; Brenna, J.T.; Murphy, K.J.; Sinclair, A.J. Gas chromatography-chemical ionization-mass spectrometric fatty acid analysis of a commercial supercritical carbon dioxide lipid extract from New Zealand green-lipped mussel (Perna canaliculus). Lipids 2005, 40, 355–360. [Google Scholar] [CrossRef]
46. Doggrell, S.A. Lyprinol-is it a useful anti-inflammatory agent? Evid. Based Complement. Altern. Med. 2011, 2011, 307121. [Google Scholar] [CrossRef][Green Version]
47. Vijarnsorn, M.; Kwananocha, I.; Kashemsant, N.; Jarudecha, T.; Lekcharoensuk, C.; Beale, B.; Peirone, B.; Lascelles, B.D.X. The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis. BMC Vet. Res. 2019, 15, 349. [Google Scholar] [CrossRef][Green Version]
48. Mongkon, N.; Soontornvipart, K. Preliminary Study of the Clinical Outcome of Using PCSO-524 Polyunsaturated Fatty Acid Compound in the Treatment of Canine Osteoarthritis and Degenerative Spinal Diseases. Thai J. Vet. Med. 2013, 42, 311–317. [Google Scholar]
49. Kongwut, S.; Soontornvipart, K.; Sarikaphuti, M.; Makoom, P.; Nganvongpanit, K. Effect of Serum IL-1beta of PCSO-524 and Firocoxib in Dogs Undergoing Medial Patellar Luxation Repair. Thai J. Vet. Med. 2015, 45, 639–643. [Google Scholar]
50. Garden, O.A.; Kidd, L.; Mexas, A.M.; Chang, Y.M.; Jeffery, U.; Blois, S.L.; Fogle, J.E.; MacNeill, A.L.; Lubas, G.; Birkenheuer, A.; et al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J. Vet. Intern. Med. 2019, 33, 313–334. [Google Scholar] [CrossRef][Green Version]
51. Sun, P.L.; Jeffery, U. Effect of dilution of canine blood samples on the specificity of saline agglutination tests for immune-mediated hemolysis. J. Vet. Intern. Med. 2020, 34, 2374–2383. [Google Scholar] [CrossRef]
52. Paes, G.; Paepe, D.; Meyer, E.; Kristensen, A.T.; Duchateau, L.; Campos, M.; Daminet, S. The use of the rapid osmotic fragility test as an additional test to diagnose canine immune-mediated haemolytic anaemia. Acta Vet. Scand. 2013, 55, 74. [Google Scholar] [CrossRef][Green Version]
53. Baum, K.; Telford, R.D.; Cunningham, R.B. Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run. Open Access J. Sports Med. 2013, 4, 109–115. [Google Scholar] [CrossRef][Green Version]
54. Pumpa, K.L.; Fallon, K.E.; Bensoussan, A.; Papalia, S. The effects of Lyprinol((R)) on delayed onset muscle soreness and muscle damage in well trained athletes: A double-blind randomised controlled trial. Complement. Ther. Med. 2011, 19, 311–318. [Google Scholar] [CrossRef]
55. Liu, S.; Hu, W.; Fang, Y.; Cai, Y.; Zhang, J.; Liu, J.; Ding, Y. Extraction of oil from wet Antarctic krill (Euphausia superba) using a subcritical dimethyl ether method. RSC Adv. 2019, 9, 34274–34282. [Google Scholar] [CrossRef] [PubMed][Green Version]
56. Yin, F.-W.; Zhou, D.-Y.; Liu, Y.-F.; Zhao, Q.; Zhou, X.; Song, L.; Qi, H.; Zhu, B.-W. The Forms of Fluoride in Antarctic Krill (Euphausia superba) Oil Extracted with Hexane and its Removal with Different Absorbents. J. Aquat. Food Prod. Technol. 2017, 26, 835–842. [Google Scholar] [CrossRef]
57. Mickleborough, T.D.; Sinex, J.A.; Platt, D.; Chapman, R.F.; Hirt, M. The effects PCSO-524(R), a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: A randomized, placebo controlled trial. J. Int. Soc. Sports Nutr. 2015, 12, 10. [Google Scholar] [CrossRef] [PubMed][Green Version]
58. Piek, C.J.; Junius, G.; Dekker, A.; Schrauwen, E.; Slappendel, R.J.; Teske, E. Idiopathic immune-mediated hemolytic anemia: Treatment outcome and prognostic factors in 149 dogs. J. Vet. Intern. Med. 2008, 22, 366–373. [Google Scholar] [CrossRef] [PubMed]
59. Mistry, N.; Mazer, C.D.; Sled, J.G.; Lazarus, A.H.; Cahill, L.S.; Solish, M.; Zhou, Y.Q.; Romanova, N.; Hare, A.G.M.; Doctor, A.; et al. Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2018, 314, R611–R622. [Google Scholar] [CrossRef][Green Version]
60. Zoia, A.; Gerou-Ferriani, M.; Drigo, M.; Caldin, M. Case-control study of plasma mean platelet component concentration and survival analysis for dogs with immune-mediated hemolytic anemia. J. Am. Vet. Med. Assoc. 2018, 252, 1384–1392. [Google Scholar] [CrossRef]
61. Lawson, C.; Smith, S.A.; O’Brien, M.; McMichael, M. Neutrophil Extracellular Traps in Plasma from Dogs with Immune-mediated Hemolytic Anemia. J. Vet. Intern. Med. 2018, 32, 128–134. [Google Scholar] [CrossRef][Green Version]
62. Mektrirat, R.; Rueangsri, T.; Keeratichandacha, W.; Soonsawat, S.; Boonyapakorn, C.; Pongkan, W. Polyunsaturated Fatty Acid EAB-277((R)) Supplementation Improved Heart Rate Variability and Clinical Signs in Tracheal Collapse Dogs. Front. Vet. Sci. 2022, 9, 880952. [Google Scholar] [CrossRef]
63. Doganci, A.; Eigenbrod, T.; Krug, N.; De Sanctis, G.T.; Hausding, M.; Erpenbeck, V.J.; Haddad, E.B.; Lehr, H.A.; Schmitt, E.; Bopp, T.; et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J. Clin. Investig. 2005, 115, 313–325. [Google Scholar] [CrossRef][Green Version]
64. Valencia, X.; Stephens, G.; Goldbach-Mansky, R.; Wilson, M.; Shevach, E.M.; Lipsky, P.E. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006, 108, 253–261. [Google Scholar] [CrossRef]
65. Swann, J.W.; Woods, K.; Wu, Y.; Glanemann, B.; Garden, O.A. Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLoS ONE 2016, 11, e0168296. [Google Scholar] [CrossRef][Green Version]
66. Kampa, N.; Kaenkangploo, D.; Jitpean, S.; Srithunyarat, T.; Seesupa, S.; Hoisang, S.; Yongvanit, K.; Kamlangchai, P.; Tuchpramuk, P.; Lascelles, B.D.X. Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: A prospective, block-randomized, double-blinded, placebo-controlled clinical trial. Front. Vet. Sci. 2023, 10, 1033188. [Google Scholar] [CrossRef]
67. Swann, J.W.; Szladovits, B.; Threlfall, A.J.; Garden, O.A.; Chang, Y.M.; Church, D.B.; Glanemann, B. Randomised controlled trial of fractionated and unfractionated prednisolone regimens for dogs with immune-mediated haemolytic anaemia. Vet. Rec. 2019, 184, 771. [Google Scholar] [CrossRef]
68. Sri-Jayantha, L.S.; Doornink, M.T.; Urie, B.K. Increased risk of select glucocorticoid adverse events in dogs of higher body weight. Can. Vet. J. 2022, 63, 32–38. [Google Scholar]
69. Weingart, C.; Thielemann, D.; Kohn, B. Primary immune-mediated haemolytic anaemia: A retrospective long-term study in 61 dogs. Aust. Vet. J. 2019, 97, 483–489. [Google Scholar] [CrossRef]
70. Elkholly, D.A.; Brodbelt, D.C.; Church, D.B.; Pelligand, L.; Mwacalimba, K.; Wright, A.K.; O’Neill, D.G. Side Effects to Systemic Glucocorticoid Therapy in Dogs Under Primary Veterinary Care in the UK. Front. Vet. Sci. 2020, 7, 515. [Google Scholar] [CrossRef]
71. Swann, J.W.; Skelly, B.J. Canine autoimmune hemolytic anemia: Management challenges. Vet. Med. 2016, 7, 101–112. [Google Scholar] [CrossRef][Green Version]
72. Alvarez, A.M.; Mukherjee, D. Liver abnormalities in cardiac diseases and heart failure. Int. J. Angiol. 2011, 20, 135–142. [Google Scholar] [CrossRef][Green Version]
73. Jamikorn, U.; Yibchok-anun, S. Effects of Dietary Polyunsaturated Fatty Acid Supplement on Healthy Beagle Dogs. Thai J. Vet. Med. 2014, 44, 505–511. [Google Scholar]
74. Clarke DL. Interventional radiology management of tracheal and bronchial collapse. Vet Clin North Am Small Anim Pract. (2018) 48:765–79. doi: 10.1016/j.cvsm.2018.05.0102. Hedlund CS. Tracheal collapse. Probl Vet Med. (1991) 3:229–38. 3. Tappin SW. Canine tracheal collapse. J Small Anim Pract. (2016) 57:9–17. doi: 10.1111/jsap.12436
75. Hedlund CS. Tracheal collapse. Probl Vet Med. (1991) 3:229–38. 3.
76. Tappin SW. Canine tracheal collapse. J Small Anim Pract. (2016) 57:9–17. doi: 10.1111/jsap.12436
77. Maggiore AD. Tracheal and airway collapse in dogs. Vet Clin North Am Small Anim Pract. (2014) 44:117–27. doi: 10.1016/j.cvsm.2013.09.004
78. Papaioannou V, Pneumatikos I, Maglaveras N. Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations. Front Physiol. (2013) 4:174. doi: 10.3389/fphys.2013.00174
79. Cooper TM, McKinley PS, Seeman TE, Choo TH, Lee S, Sloan RP. Heart rate variability predicts levels of inflammatory markers: evidence for the vagal anti-inflammatory pathway. Brain Behav Immun. (2015) 49:94–100. doi: 10.1016/j.bbi.2014.12.017
80. Yan M, Mehta JL, Zhang W, Hu C. LOX-1, oxidative stress and inflammation: a novel mechanism for diabetic cardiovascular complications. Cardiovasc Drugs Ther. (2011) 25:451–9. doi: 10.1007/s10557-011-6342-4
81. Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev. (2016) 2016:7432797. doi: 10.1155/2016/7432797
82. Khoubnasabjafari M, Ansarin K, Jouyban A. Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders. Bioimpacts. (2015) 5:123–7. doi: 10.15171/bi.2015.20
83. Cygankiewicz I, Zareba W. Heart rate variability. Handb Clin Neurol. (2013) 117:379–93. doi: 10.1016/B978-0-444-53491-0.00031-6
84. Chueainta P, Pongkan W, Boonyapakorn C. Clinical applications of heart rate variability in dogs. Vet Integr Sci. (2019) 17:195–220.
85. Lahdenoja O, Hurnanen T, Kaisti M, Koskinen J, Tuominen J, Vähä-Heikkilä M, et al. Cardiac monitoring of dogs via smartphone mechanocardiography: a feasibility study. Biomed Eng Online. (2019) 18:47. doi: 10.1186/s12938-019-0667-9
86. Thio CHL, van Roon AM, Lefrandt JD, Gansevoort RT, Snieder H. Heart rate variability and its relation to chronic kidney disease: results from the PREVEND study. Psychosom Med. (2018) 80:307–16. doi: 10.1097/PSY.0000000000000556
87. Chou YH, Huang WL, Chang CH, Yang CCH, Kuo TBJ, Lin SL, et al. Heart rate variability as a predictor of rapid renal function deterioration in chronic kidney disease patients. Nephrology. (2019) 24:806–13. doi: 10.1111/nep.13514
88. Serrao NF Jr., Porta A, Minatel V, Castro AAM, Catai AM, Sampaio LMM, et al. Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms. Clin Auton Res. (2020) 30:157–64. doi: 10.1007/s10286-019-00659-z
89. Li Y, Wang J, Li X, Jing W, Omorodion I, Liu L. Association between heart rate variability and Parkinson’s disease: a meta-analysis. Curr Pharm Des. (2021) 27:2056–67. doi: 10.2174/1871527319666200905122222 17. Lucini D, Pagani M. Heart rate variability, autonomic regulation and myocardial ischemia. Int J Cardiol. (2020) 312:22–3. doi:10.1016/j.ijcard.2020.03.012
90. Tan JPH, Beilharz JE, Vollmer-Conna U, Cvejic E. Heart rate variability as a marker of healthy ageing. Int J Cardiol. (2019) 275:101–3. doi: 10.1016/j.ijcard.2018.08.005
91. Alfonso A, Le Sueur ANV, Geraldes SS, Guimaraes-Okamoto PTC, Tsunemi MH, Santana DF, et al. Heart rate variability and electrocardiographic parameters predictive of arrhythmias in dogs with stage IV chronic kidney disease undergoing intermittent haemodialysis. Animals. (2020) 10:1829. doi: 10.3390/ani10101829
92. Petrie JP. Practical application of holter monitoring in dogs and cats. Clin Tech Small Anim Pract. (2005) 20:173–81. doi: 10.1053/j.ctsap.2005.05.00615
93. Hsieh BM, Beets AK. Coughing in small animal patients. Front Vet Sci. (2020) 6:513. doi: 10.3389/fvets.2019.00513
94. Williams J, editor. Management of tracheal collapse. World Small Animal Veterinary Association World Congress Proceedings. Cape Town (2014).
95. Della Maggiore A. An update on tracheal and airway collapse in dogs. Vet Clin North Am Small Anim Pract. (2020) 50:419–30. doi: 10.1016/j.cvsm.2019.11.003
96. Shei RJ, Adamic EM, Chapman RF, Mickleborough TD. The effects of PCSO524(R), a patented marine oil lipid derived from the New Zealand green lipped mussel (Perna canaliculus), on pulmonary and respiratory muscle function in non-asthmatic elite runners. Int J Exerc Sci. (2018) 11:669–80.
97. Vijarnsorn M, Kwananocha I, Kashemsant N, Jarudecha T, Lekcharoensuk C, Beale B, et al. The effectiveness of marine based fatty acid compound (PCSO524) and firocoxib in the treatment of canine osteoarthritis. BMC Vet Res. (2019) 15:349. doi: 10.1186/s12917-019-2110-7
98. Zhu B, Zhang Y, Herrup K. Testing the neuroprotective properties of PCSO524((R)) using a neuronal cell cycle suppression assay. Mar Drugs. (2019) 17:79. doi: 10.3390/md17020079
99. Mickleborough TD, Sinex JA, Platt D, Chapman RF, Hirt M. The effects PCSO-524(R), a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a randomized, placebo controlled trial. J Int Soc Sports Nutr. (2015) 12:10. doi: 10.1186/s12970-015-0073-z
100. Doggrell SA. Lyprinol-is it a useful anti-inflammatory agent? Evid Based Complement Alternat Med. (2011) 2011:307121. doi: 10.1093/ecam/nep030
101. Mickleborough TD, Vaughn CL, Shei RJ, Davis EM, Wilhite DP. Marine lipid fraction PCSO-524 (lyprinol/omega XL) of the New Zealand green lipped mussel attenuates hyperpnea-induced bronchoconstriction in asthma. Respir Med. (2013) 107:1152–63. doi: 10.1016/j.rmed.2013.04.010
102. Mongkon N, Soontornvipart K. Preliminary study of the clinical outcome of using PCSO-524 polyunsaturated fatty acid compound in the treatment of canine osteoarthritis and degenerative spinal diseases. Thai J Vet Med. (2012) 42:311–7. 31. Mateos R, Lecumberri E, Ramos S, Goya L, Bravo L. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress: application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J Chromatogr B Analyt Technol Biomed Life Sci. (2005) 827:76–82. doi: 10.1016/j.jchromb.2005.06.035
103. Pongkan W, Pintana H, Jaiwongkam T, Kredphoo S, Sivasinprasasn S, Chattipakorn SC, et al. Vildagliptin reduces cardiac ischemic-reperfusion injury in obese orchiectomized rats. J Endocrinol. (2016) 231:81–95. doi: 10.1530/JOE-16-0232 33. Pongkan W, Jitnapakarn W, Phetnoi W, Punyapornwithaya V, Boonyapakorn C. Obesity-induced heart rate variability impairment and decreased systolic function in obese male dogs. Animals. (2020) 10:1383. doi: 10.3390/ani10081383
104. Bogucki S, Noszczyk-Nowak A. Short-term heart rate variability (HRV) in healthy dogs. Pol J Vet Sci. (2015) 18:307–12. doi: 10.1515/pjvs-2015-0040 35. von Borell E, Langbein J, Despres G, Hansen S, Leterrier C, Marchant-Forde J, et al. Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals – a review. Physiol Behav. (2007) 92:293–316. doi: 10.1016/j.physbeh.2007.01.007
105. Lima AH, Forjaz CL, Silva GQ, Meneses AL, Silva AJ, Ritti-Dias RM. Acute effect of resistance exercise intensity in cardiac autonomic modulation after exercise. Arq Bras Cardiol. (2011) 96:498–503. doi: 10.1590/S0066-782X2011005000043
106. Latchman PL, Mathur M, Bartels MN, Axtell RS, De Meersman RE. Impaired autonomic function in normotensive obese children. Clin Auton Res. (2011) 21:319–23. doi: 10.1007/s10286-011-0116-8
107. Kenneth S, Edward A, Keith W. Duncan and Prasses’s Veterinary Laboratory Medicine Clinical Pathology. 4 ed. Ames, IA: Iowa State Press. (2003).
108. Regier PJ, Grosso FV, Stone HK, van Santen E. Radiographic tracheal dimensions in brachycephalic breeds before and after surgical treatment for brachycephalic airway syndrome. Can Vet J. (2020) 61:971–6.
109. Jepsen-Grant K, Pollard RE, Johnson LR. Vertebral heart scores in eight dog breeds. Vet Radiol Ultrasound. (2013) 54:3–8. doi: 10.1111/j.1740-8261.2012.01976.x
110. Vezzosi T, Puccinelli C, Tognetti R, Pelligra T, Citi S. Radiographic vertebral left atrial size: a reference interval study in healthy adult dogs. Vet Radiol Ultrasound. (2020) 61:507–11. doi: 10.1111/vru.12896
111. Zawadzki M, Janosch C, Szechinski J. Perna canaliculus lipid complex PCSO524 demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. Mar Drugs. (2013) 11:1920–35. doi: 10.3390/md11061920
112. Malik M. Producing consistent estimates of the power spectral density of NN sequences. Circulation. (1997) 96:2082–3.
113. Shukla RS, Aggarwal Y. Time-domain heart rate variability-based computer-aided prognosis of lung cancer. Indian J Cancer. (2018) 55:61–5. doi: 10.4103/ijc.IJC_395_17
114. Kleiger RE, Stein PK, Bigger JT Jr. Heart rate variability: measurement and clinical utility. Ann Noninvasive Electrocardiol. (2005) 10:88–101. doi: 10.1111/j.1542-474X.2005.10101.x
115. Pongkan W, Pintana H, Sivasinprasasn S, Jaiwongkam T, Chattipakorn SC, Chattipakorn N. Testosterone deprivation accelerates cardiac dysfunction in obese male rats. J Endocrinol. (2016) 229:209–20. doi: 10.1530/JOE-16- 0002
116. Sivasinprasasn S, Sa-Nguanmoo P, Pongkan W, Pratchayasakul W, Chattipakorn SC, Chattipakorn N. Estrogen and DPP4 inhibitor, but not metformin, exert cardioprotection via attenuating cardiac mitochondrial dysfunction in obese insulin-resistant and estrogen-deprived female rats. Menopause. (2016) 23:894–902. doi: 10.1097/GME.00000000000 00640
117. Pavithran P, Nandeesha H, Sathiyapriya V, Bobby Z, Madanmohan T. Short-term heart variability and oxidative stress in newly diagnosed essential hypertension. Clin Exp Hypertens. (2008) 30:486–96. doi: 10.1080/10641960802251875
118. Pongkan W, Jinawong K, Pratchayasakul W, Jaiwongkam T, Kerdphoo S, Tokuda M, et al. D-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats. Eur J Nutr. (2020). doi: 10.1007/s00394-020- 02394-y
119. Balasubramanian P, Asirvatham-Jeyaraj N, Monteiro R, Sivasubramanian MK, Hall D, Subramanian M. Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. (2020) 318:R435–r44. doi: 10.1152/ ajpregu.00206.2019
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