PCSO-524® Report Clinical Results of Nineteen Dogs with Tracheal Collapse that received PCSO-524®, a Lipid Extract of the New Zealand Green-Lipped Mussel (Perna canaliculus)
Tracheal collapse is a respiratory disorder characterized by the decrease of supporting force of the tracheal cartilage which results in abnormal dilating and flattening of the trachea. It is common in small-breed dogs and brachycephalic dogs. Tracheal collapse results from a number of causes including genetic factors, obesity, tracheal cartilage degeneration, chronic bronchitis, respiratory infection, and cardiovascular dysfunction. The combination with these causes worsens symptoms.
Comprehensive management is required such as medical treatment as well as surgical treatment at the time of progression.
A study has reported that polysulfated glycosaminoglycan (Adequan®), which is used to treat articular cartilage disease, has been observed to apparently reduce clinical symptoms such as coughing associated with tracheal collapse, through it’s restoring effect on tracheal cartilage similar to that it has on articular cartilage. 
Based on this finding as well as the other report stating that fatty acids of green-lipped mussels (Perna viridis) have a pain-relief effect in New Zealand people with arthralgia, Adequan® was given to approximately 200 dogs with arthralgia at our hospital between 1987 and 1991. The effect in dogs was similar to that in human patients.
This report summarize positive effects of PCSO-524® (Antinol®), a supplement product which includes anti-inflammatory fatty acids extracted from Perna canaliculus, another kind of green-lipped mussels, given to dogs with tracheal collapse.
Case: Nineteen dogs presented with cough and diagnosed with tracheal collapse based on inspiration / expiration chest radiography between December 2013 and April 2015.
Published on Journal of Modern Veterinary Medicine (MVM) Vol.25 No.163 (2016)