Use of PCSO-524® for Control of Inflammation Caused by Iris Tumorand Uveitis in Cats with Lymphoma and Chronic Kidney Disease

Antinol® Case Study 2018 Content

3rd Winning Award

Use of PCSO-524® for Control of Inflammation Caused by Iris Tumorand Uveitis in Cats with Lymphoma and Chronic Kidney Disease

Nuanwan Rujirekasuwan, DVM, Faculty of Veterinary Medicine, Kasetsart University, Bang Khun Campus, Thailand

Honorable Committee

1) Associate Professsor, Dr.Rosama Pusoonthornthum, Veterinary Science, Chulalongkorn University

2) Assistant Professor Dr.Monchanok Vijarnsorn, Veterinary Medicine, Kasetsart University

3) Assistant Professor Dr.Walasinee Sakcamduang, Veterinary Science, Mahidol University

4) Assistant Professor Dr.Kumpanart Sundaravibhata, Veterinary Science, Chulalongkorn University

5) Dr. Chaiyot Tanrattana, Veterinary Science, Chulalongkorn University

6) Assistant Professor Dr.Tassanee Jaroensong, Veterinary Medicine, Kasetsart University

Abstract

A neutered male Domestic Shorthair cat aged 8 years was infected with FIV and diagnosed with nasal submucosa-T-cell lymphoma that was positive to CD3.

After the chemotherapy, the cat showed improvement of respiration. However, azotemia and leukopenia were detected, so the therapy was discontinued after the second session. Leukopenia and high creatinine were treated until the normal conditions were resumed.

Four months later, tumor of iris and uveitis were found in the left eye. Treatment of inflammation of the left eye included prednisolone acetate 1% eye drop (lnf-oph® 1 %, Seng Thai company; Thailand) qid, doxycycline (Siadocin®, Siam Bheasach; Thailand) PO at the dose 10 mg/kg/day, prednisolone (Prednisolone GPO; Thailand) PO0.36 mg/kg bid.

Two weeks later, the size of tumor remained constant, the inflammation degree was reduced but creatinine level was increased. Administration of oral prednisolone, not the eye drop, was then terminated. Uveitis of the right eye was diagnosed and also fibrin in the anterior chamber and tumor of the iris were found in the right eye. Prednisolone acetate 1% eye drop was prescribed for both eyes.

The inflammation of both eyes still existed after 1 month of the prednisolone treatment. Green Lipped mussel extract, PCSO-524® (VetzPetz Antinol®, DKSH, Thailand), 1 capsule per day was then prescribed as an alternative of steroidal medication for control of inflammation, together with the prednisolone acetate 1 % eye drop in both eyes.

After 30 days of the start of PCSO-524® treatment, the tumor of iris disappeared and the severity of uveitis was reduced in both eyes.

Keywords: Cat, uveitis, lymphoma, azotemia, PCSO-524®