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Application of the Polyunsaturated fatty acid compound PCSO-524 in the post operative recovery of dogs that have had stifle surgery
World Small Animal Veterinary Assoc.
38th Annual Congress 6-9 March 2013, Auckland, New Zealand
The clinical outcomes of the use of PCSO-524 in 28 dogs that had undergone surgery on the stifle (which included correction of the patellar luxation and correction of cranial cruciate ligament rupture) were studied at the Small Animal Teaching Hospital, at Chulalongkorn University, Bangkok, Thailand.
Twenty-eight dogs that undergone both stifle surgery were included in our study. All test subjects had been given pre-emptive analgesia (morphine sulfate). NSAIDs and glucosamine had been administered before the surgery.
Two postoperative treatments were:
- NSAIDs treatment for one week in combination with glucosamine sulfate;
- only PCSO-524 treatments.
The Effects of PCSO-524 Extract on Vital Signs, Complete Blood Count, and Blood Chemistry in Clinically-Healthy Normal Cats
Authors:
Chronic pain is commonly caused by degenerative disease, which is under diagnosed in cats.
PCSO-524 is an extract of Perna canaliculus, a known source of Omega-3 polyunsaturated fatty acids (PUFAs) with anti-inflammatory properties. Lipids extracted from the New Zealand green-lipped mussel (NZGLM) contain a complex mixture of mainly phospholipids (PL, 57-79%), triglycerides (TG, 10-25%), free fatty acids (FFA, 7-12%) and sterols (ST, 12-18%)
PCSO-524 is a source of omega-3 polyunsaturated fatty acids with anti-inflammatory properties commonly used to treat osteoarthritis in human beings and dogs.
The purpose of this study was to study the effects of PCSO-524 extract on vital signs, completed blood count, and blood chemistry in clinically-healthy normal cats.
The Preliminary study of the Clinical outcome of using the PCSO-524 polyunsaturated fatty acid compound (Antinol) in the treatment of Canine Osteoarthritis and degenerative spinal diseases
Authors:
The clinical outcome of PCSO-524 application in the treatment of canine osteoarthritis and spinal disorder was studied at the Small Animal Teaching Hospital, Chulalongkorn University.
Eighty-four dogs were included in our study. Thirty-one dogs showed signs of osteoarthritis (OA) in both hip joints and shoulder joints; 33 dogs had OA in stifle joints from cranial cruciate ligament rupture; and 20 dogs had neurological signs of the cauda equina syndrome.
All affected dogs were treated by 50 mg/ 10 kg of PCSO-524, PO for twelve weeks.
Use of Acupuncture in Combination with PCSO-524® (Antinol®) for Treatment of Hindlimb Paresis in Prairie Dogs
Authors:
A prairie dog was admitted to the hospital due to falling from a height accident.
During 2 weeks of admission, the animal was treated with steroid and vitamin B, however, no response was observed.
Alternative medicine; acupuncture, was then applied in combination with PCSO-524® (Antinol®) to enhance the effects of acupuncture on pain relief and repairing the damaged neurons.
Excellent recovery was observed after 1 month of the treatment.
The animal could stand in normal position, express other normal gestures, and the reflex was nearly fully recovered.
PCSO-524® as Supportive Therapy for Generalized Alopcia in Guinea Pigs
Authors:
Skin diseases are common in guinea pigs. Most frequently identified cause is improper management, for example, high humidity, unhygienic environment, nutrient deficiency, and high density, which may result in skin irritation leading to complications and alopecia. Hair growth mechanism in guinea pigs is affected by several factors such as photoperiod, environmental temperature, nutrition, physical health, stress, genetics, and some other internal factors.
The aim of using PCSO-524® for supportive therapy of general alopecia is to reduce the skin irritation and to improve the skin and hair condition.
Previous pilot studies showed that the treatment is effective for hair growth and improvement of hair condition in various exotic pets. Therefore the objective of this study is to study the efficacy of PCSO-524® for treatment of general alopecia and skin irritation due to scabies mite infestation and fungal infection in guinea pigs.
The ultimate goal is to find alternative treatment to other anti-inflammatory medications and to reduce the quantity and frequency of medication use in guinea pigs, the species that is known to be difficult for medication administration.
The Use of Cyclosporine and PCSO-524® in the Treatment of Alopecia and Dermatitis due to Sebaceous Adenitis in Rabbits
Authors:
Female Holland Lop rabbit aged 9 years and 6 months was taken to the hospital for treatment of dermatitis.
Clinical signs included alopecia with unknown cause, dry and course hair, scaling, dry and cracked skin.
The laboratory examination consisted of superficial skin scraping, cellophane tape technique and dermatophyte test kit examination.
External parasites, yeast, and fungi were not found. However, skin biopsy identified hyperkeratosis, follicular dystrophy, and decreased number of sebaceous gland.
After sebaceous adenitis was diagnosed, the rabbit was treated with 5mg/kg cyclosporine sid and 1 capsule of PCS0-524® sid for more than 6 months in order to reduce the skin inflammation and hairrestoration.
No adverse effects were found and the hair loss was replaced by new hair growth, softer hair and less scaling was observed.
Antinol® Case Study Contest 2016
Authors:
The 10 Case Studies from Antinol® Case Study Contest of 2016.
1st Winning Awards
1) Effects of PCSO-524® on Inflammation Control in Cats with Chronic Renal Disease after Keratectomy and Conjunctival Pedicle Graft for Treatment of Corneal Sequestrum from Indolent Ulcer
2) The Use of Cyclosporine and PCSO-524® in the Treatment of Alopecia and Dermatitis due to Sebaceous Adenitis in Rabbits
2nd Winning Awards
3) Use of PCSO-524® in Combination with Prednisolone for Treatment of Spinal Cord Injury from Disc Protrusion in Dogs
4) Effects of PCSO-524® on Treatment of Cranial Cruciate Ligament Rupture in Dogs after Tibial Plateau Leveling Osteotomy (TPLO) and Physical Rehabilitation
5) The Treatment of Medial Coronoid Disease in a Seven Months Old Labrador Retriever
3rd Winning Awards
6) A Study of Efficacy and Safety of PCSO-524® (Antinol®l in Treatment of Medial Patellar Luxation and Cranial Cruciate Ligament Rupture in a Yorkshire Terrier Dog
7) Effects of PCSO-524® (Antinol®l Supplementation during 12 Months Follow-up in 2 Cats with Cystitis and Chronic Renal Disease
8) Use of PCSO-524® (Antinol®) for Treatment of Nervous Disorder Caused by Car Accident and Hip Osteoarthritis in Geriatric Cats
9) PCSO-524® as Supportive Therapy for Generalized Alopcia in Guinea Pigs
10) Use of Acupuncture in Combination with PCS0-524® (Antinol®l for Treatment of Hindlimb Paresis in Prairie Dogs
Anti-inflammatory activity of
a lipid fraction (lyprinol) from the
NZ green-lipped mussel
Updated Study Topics
New researches and publications related to PCSO-524® and its result in clnical test submitted by veterinarians on the global conferences every year and the data keeps growing with more studies conducted
