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Efficacy of PCSO-524® (VetzPetz Antinol®) for Inflammation Control in Cat with Chronic Juvenile Gingivitis Responsive to Full Mouth Extraction
Authors:
The cat was having signs of juvenile gingivitis and retained deciduous dentition. Extraction of deciduous teeth were performed when the cat was 11 months old. However, gingivitis was persistent and causing severe halitosis, saliva stain on hair around the lips, drooling, and gingival overgrowth.
The cat was treated with New Zealand green-lipped mussel oil extract PCSO-524® (VetzPetz Antinol®, DKSH, Thailand) 1 capsule daily for 2 months after the extraction of deciduous teeth.
The treatment was able to reduce degree of drooling and gingivitis but could not completely eliminate the disease.
Full mouth extraction was then performed.
Post-operative care included anti-inflammatory drug, Tolfenamic acid (Tolfedine®, Vétoquinol, Best Agro; Thailand) 4 mg/kg for 3 consecutive days, Amoxicillin-Clavulanic acid (Clavamox®, Zoetis, Thailand12.5 mg/kg for 1 week, and New Zealand green-lipped mussel oil extract PCSO-524® (VetzPetz Antinol®, DKSH, Thailand) 1 capsule per day continuously.
The severity of gingivitis was rapidly decreased after the operation and within 2 weeks after the operation, the gingivitis was completely subsided.
The oil extract was administered continuously for 31 months without showing any clinical signs or impaired hematological indicators.
Treatment of Severe Hind Limb Paresis and Posterior Paresis Caused by Traumatic Myelopathy in Cats Using PSCO-524® (Antinol®) and Physical Therapy
Authors:
A 2 years old domestic short hair cat weighted 3.55 kilograms was referred to Kasetsart University Veterinary Hospital for severe hind limb paresis with loss of sensory function. The onset of symptoms was observed a week ago after the cat returned from missing. Radiographic examination did not show any vertebral disorders. Magnetic Resonance Imaging (MRI) examination found accumulation of fluid in spinal cord at T10-T12 level, which indicated spinal cord injury. Traumatic myelopathy was diagnosed.
The paresis was grade 5 so PSCO-524® (Antinol®) 1 capsule per day was prescribed. After a week of the treatment, the cat was able to control urination and voluntary motor function of the hind limbs.
However, the sensory system malfunction remained. Spinal walk, walking with the hind limbs when sensation loss was observed after physical therapy was concurrently provided for 3 weeks.
Efficacy of Oral PCSO-524®
as an Anti-Inflammatory Medicationin a Persian Cat with Pruritic Skin Disease
Authors:
This is a case report of a Persian cat with severe pruritus, which was not improved by topical external parasitic treatment, food trial and 2 months treatment with oral cyclosporine at the dose 5mg/kg. The cat developed corneal ulcer after the long-term treatment with oral cyclosporine.
PCSO-524® (Antinol® Vetz Petz, New Zealand) was replaced cyclosporine as an anti-inflammation treatment and also was considered as a skin barrier support.
The cause of pruritic in this case report was still inconclusive, but the skin lesions of this cat resolved after 2 months supplement with oral PCSO-524® and external parasitic treatment with oral f vluralaner (Bravecto®, MSD).
In conclusion, oral PCSO-524® (Antinol®, Vetz Petz), could be considered as an anti-inflammation and skin barrier support when the cats could not be treated with potent anti-inflammatory medications such as corticosteroid or cyclosporine. The underlying causes of pruritic skin lesions should be corrected in order to manage feline pruritic skin diseases.
Effect of PCSO-524® Supplement on Inflammation and Pain Control and Its Safety for Orthopedic Surgery in Pregnant Cats
Authors:
Bone fracture is common in stray cats. It can cause severe pain and requires surgical treatment.
Use of non-steroidal anti-inflammatory drugs (NSAIDs) or opioid drugs is common for control of pain from bone fracture. However, adverse effects are frequently reported for NSAIDs and opioid use.
Objective of this study is to evaluate anti-inflammatory and pain-relieving effects and safety of PCSO-524® (Antinol®) for bone surgery in pregnant cats.
The Trial Treatment of Feline Osteoarthritis in an Eleven-Year-Old Cat
Authors:
A domestic short hair cat aged 11 years was taken to the hospital due to shaking and weakened hind legs. The cat could not perform high jump for 1 month.
Preliminary diagnosis included early stage of osteoarthritis of left hip and capsulitis.
Pain killers, NSAIDs and gabapentin, were administered but the response was not satisfied. Therefore, multimodal treatment program was initiated. Physical therapy using electrical stimulation and laser beam class 4 in conjunction with PCSO-524® were used. Measurement of joint movement angle (active range of motion; active ROM) in 2 dimensions using Kinovea program was conducted for follow up.
The study found increased active ROM and decreased lameness score after the treatment.
The owner described that the cat showed less isolation behavior and was able to perform vertical jump again. Overall quality of the cat’s life was improved.
Use of PCSO-524® (Antinol)® for treatment of Obsessive-Compulsive Disorders (OCD) in Domestic Short Hair Cat
Authors:
A 3 years old domestic short hair cat had shown behavioral disorder after castration 4 months ago.
The clinical signs were consistent with obsessive-compulsive disorders (OCD).
Pathological examination found edema of epidermis andinfiltration of mature mast cells in hair follicle. Treatment with PCSO-524® (Antinol)® for 180 days had shown that the misbehavior was improved due to decreased pain and skin inflammation. Healthier coat and skin appearance was noticed after 30 consecutive days of PCSO-524® (Antinol®) intake. Pathological follow-up showed less inflammation of epidermis and decreased mast cells infiltration.
It was shown that PCSO-524® (Antinol®) could reduce pain and inflammation that caused anxiety and consequently OCD in cats. Additional effects included antihistamine, antiallergy, and skin neurishing.
Use of PCSO-524® (Antinol®) for Treatment of Nervous Disorder Caused by Car Accident and Hip Osteoarthritis in Geriatric Cats
Authors:
Male castrated Persian cat aged 12 years was injured at the rear body in an automobile accident causing paralysis of the hind limbs.
X-ray examination found luxation of both pelvic joints and osteoarthritis of hip joint. Nervous disorder of the hind limbs was diagnosed from the absence of the motor and deep pain sensory impulse. MRI examination found no spinal cord damage.
The treatment included electrical stimulation at the hind limb muscle in combination with long-term administration of PCSO-524® (Antinol®).
The hind limbs were functional normally at the end of the treatment and blood chemistry examination at 32 weeks after the treatment showed normal liver and kidney indicators.
Effects of PCSO-524® (Antinol®) Supplementation during 12 Months Follow-up in 2 Cats with Cystitis and Chronic Renal Disease
Authors:
Two female cats, spayed, lived in the same house, aged 17 years weighted 2.2 kg and 10 years 4.4 kg, were having chronic renal failure and concurrent cystitis.
Both cats were treated with fluid therapy intravenously in the early period and later subcutaneously. The diet was changed to diet formulated for cats with renal failure (Hill’s Prescription diet k/d) for both cats. Avastamine (RenAvastTM) 1 capsule bid for 1 month, Cystaid® cat (Acetyl 0-Glucosamine: NAG125 mg) l capsule bid for 1 month, and PCSO-524® (Vetz Petz Antinol®) 1 capsule sid continuously were prescribed for the first cat. The second cat received only PCSO-524® (Vetz Petz Antinol®) 1 capsule sid continuously.
The treatment results showed general health improvement, weight gain (2.6 kg and 5.1 kg in the first and second cat, respectively), less hair loss, decreased degree of polydipsia and polyuria, and improvement of blood parameters.
No adverse effect of the continuous treatment was found after 18 and 13 months in the first and second cat, respectively.
Effects of PCSO-524® on Inflammation Control in Cats with Chronic Renal Disease after Keratectomy and Conjunctival Pedicle Graft for Treatment of Corneal Sequestrum from Indolent Ulcer
Authors:
A female spayed cat aged 13 years with chronic renal disease later affected with indolent ulcer, and consequently followed by corneal sequestrum.
After azotemia was controlled, the cat was surgically treated with keratectomy that used conjunctival pedicle graft for suture closure.
The cat received 4mg/kg Tolfenamic acid (Tolfedine®, Vetoquinol, Best Agro; Thailand) for 3 days, 2.5 mg/kg Doxycycline monohydrate (Vibravet®, Zoetis, Thailand) for 2 weeks and 1 tablet per day of New Zealand Green-lipped mussel extract, PCSO-524® (Vetz Petz Antinol®, DKSH, Thailand) for long-term control of inflammation.
The latter was used as an antioxidant and alternative to Non-steroid, which is a contradiction for chronic renal failure.
The cat showed decreased severity of inflammation, normal clinical symptoms, and fine control of azotemia.
It is concluded that PCSO-524® (Vetz Petz Antinol®) can be used to support long-term anti-inflammation treatment and reduce the damage in cats with medical contraindication due to chronic renal disease
The Effects of PCSO-524 Extract on Vital Signs, Complete Blood Count, and Blood Chemistry in Clinically-Healthy Normal Cats
Authors:
Chronic pain is commonly caused by degenerative disease, which is under diagnosed in cats.
PCSO-524 is an extract of Perna canaliculus, a known source of Omega-3 polyunsaturated fatty acids (PUFAs) with anti-inflammatory properties. Lipids extracted from the New Zealand green-lipped mussel (NZGLM) contain a complex mixture of mainly phospholipids (PL, 57-79%), triglycerides (TG, 10-25%), free fatty acids (FFA, 7-12%) and sterols (ST, 12-18%)
PCSO-524 is a source of omega-3 polyunsaturated fatty acids with anti-inflammatory properties commonly used to treat osteoarthritis in human beings and dogs.
The purpose of this study was to study the effects of PCSO-524 extract on vital signs, completed blood count, and blood chemistry in clinically-healthy normal cats.
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New researches and publications related to PCSO-524® and its result in clnical test submitted by veterinarians on the global conferences every year and the data keeps growing with more studies conducted
