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Use of PCSO-524® for Control of Inflammation Caused by Iris Tumorand Uveitis in Cats with Lymphoma and Chronic Kidney Disease
Authors:
A neutered male Domestic Shorthair cat aged 8 years was infected with FIV and diagnosed with nasal submucosa-T-cell lymphoma that was positive to CD3.
Four months later, tumor of iris and uveitis were found in the left eye. Treatment of inflammation of the left eye included prednisolone acetate 1% eye drop (lnf-oph® 1 %, Seng Thai company; Thailand) qid, doxycycline (Siadocin®, Siam Bheasach; Thailand) PO at the dose 10 mg/kg/day, prednisolone (Prednisolone GPO; Thailand) PO0.36 mg/kg bid.
Two weeks later, the size of tumor remained constant, the inflammation degree was reduced but creatinine level was increased. Administration of oral prednisolone, not the eye drop, was then terminated. Uveitis of the right eye was diagnosed and also fibrin in the anterior chamber and tumor of the iris were found in the right eye. Prednisolone acetate 1% eye drop was prescribed for both eyes.
The inflammation of both eyes still existed after 1 month of the prednisolone treatment. Green Lipped mussel extract, PCSO-524® (VetzPetz Antinol®, DKSH, Thailand), 1 capsule per day was then prescribed as an alternative of steroidal medication for control of inflammation, together with the prednisolone acetate 1 % eye drop in both eyes.
After 30 days of the start of PCSO-524® treatment, the tumor of iris disappeared and the severity of uveitis was reduced in both eyes.
Clinical Effect of PCSO-524® on 3 Osteoarthritic Cats Associated with Chronic Kidney Disease
Authors:
Three cats suffering from chronic kidney disease were admitted to animal hospital.
The first cat showed sudden onset of right hindlimb pain without apparent cause. Bladder stone was found in the second cat while the third cat was admitted for nursing care. Caging was applied and fluid therapy were administered for the third cat. All 3 cats had never been diagnosed with arthritis prior to the admission.
X-ray examination showed symptoms of arthritis at hip and stifle joints. PCSO-524® was then administered daily for 60 days.
Pain evaluation using Feline Musculoskeletal Pain Index (FMPI), which is a reliable and effective method for pain evaluation in cats (Benito et al., 2013), showed that, after the treatment, chronic pain was decreased in all of the cats (Appendix 1). The cats’ behavior was nearly normal compared with the behavior before the treatment. Interaction between the cats and owners was improved as well.
By the end of the experiment, UP/C ratio was not altered and blood creatinine tended to decrease.
Nutraceutical Treatment of Feline Fhne and Hip Dysplasia in an 8-Month Old Cat
Authors:
A Persian male cat was diagnosed with right hip luxation and left hip injury. While waiting for surgical treatment, the cat was treated with NSAIDs to control pain and inflammation.
After the operation on the right femoral head (right FHNE), the cat received antibiotics and NSAIDs for 10 and 3 consecutive days, respectively. Two weeks after the operation, the lameness and pain of the right hip, as observed from palpation, still remained, but the cat began to bear partial weight.
PCSO-524® was then prescribed and the gait analysis was performed to measure the angle of joint movement.
The monitoring showed increased angle of joint movement and decreased lameness score. This was consistent with the owner report that described less hiding behavior of the cat and improved high jump performance and better quality of life.
Antinol® Case Study Contest 2017
10 Case Reports using PCSO-524® in combination with the treatment regimen for dogs and cats.
Pharmalink International Ltd. and Vetz Petz® would like to thank everyone involved in this 2017 Antinol® Case Study Contest competition and pay homage to our Professors and Veterinarians who have assisted in the judging of the competition.
This 2017 contest was very special with the inclusion of Professor Duncan Lascelles and the wonderful innovation of the live poll that the audience took part in to choose the Vets choice and favorite presentation.
Efficacy of PCSO-524® (VetzPetz Antinol®) for Inflammation Control in Cat with Chronic Juvenile Gingivitis Responsive to Full Mouth Extraction
Authors:
The cat was having signs of juvenile gingivitis and retained deciduous dentition. Extraction of deciduous teeth were performed when the cat was 11 months old. However, gingivitis was persistent and causing severe halitosis, saliva stain on hair around the lips, drooling, and gingival overgrowth.
The cat was treated with New Zealand green-lipped mussel oil extract PCSO-524® (VetzPetz Antinol®, DKSH, Thailand) 1 capsule daily for 2 months after the extraction of deciduous teeth.
The treatment was able to reduce degree of drooling and gingivitis but could not completely eliminate the disease.
Full mouth extraction was then performed.
Post-operative care included anti-inflammatory drug, Tolfenamic acid (Tolfedine®, Vétoquinol, Best Agro; Thailand) 4 mg/kg for 3 consecutive days, Amoxicillin-Clavulanic acid (Clavamox®, Zoetis, Thailand12.5 mg/kg for 1 week, and New Zealand green-lipped mussel oil extract PCSO-524® (VetzPetz Antinol®, DKSH, Thailand) 1 capsule per day continuously.
The severity of gingivitis was rapidly decreased after the operation and within 2 weeks after the operation, the gingivitis was completely subsided.
The oil extract was administered continuously for 31 months without showing any clinical signs or impaired hematological indicators.
Treatment of Severe Hind Limb Paresis and Posterior Paresis Caused by Traumatic Myelopathy in Cats Using PSCO-524® (Antinol®) and Physical Therapy
Authors:
A 2 years old domestic short hair cat weighted 3.55 kilograms was referred to Kasetsart University Veterinary Hospital for severe hind limb paresis with loss of sensory function. The onset of symptoms was observed a week ago after the cat returned from missing. Radiographic examination did not show any vertebral disorders. Magnetic Resonance Imaging (MRI) examination found accumulation of fluid in spinal cord at T10-T12 level, which indicated spinal cord injury. Traumatic myelopathy was diagnosed.
The paresis was grade 5 so PSCO-524® (Antinol®) 1 capsule per day was prescribed. After a week of the treatment, the cat was able to control urination and voluntary motor function of the hind limbs.
However, the sensory system malfunction remained. Spinal walk, walking with the hind limbs when sensation loss was observed after physical therapy was concurrently provided for 3 weeks.
Efficacy of Oral PCSO-524®
as an Anti-Inflammatory Medicationin a Persian Cat with Pruritic Skin Disease
Authors:
This is a case report of a Persian cat with severe pruritus, which was not improved by topical external parasitic treatment, food trial and 2 months treatment with oral cyclosporine at the dose 5mg/kg. The cat developed corneal ulcer after the long-term treatment with oral cyclosporine.
PCSO-524® (Antinol® Vetz Petz, New Zealand) was replaced cyclosporine as an anti-inflammation treatment and also was considered as a skin barrier support.
The cause of pruritic in this case report was still inconclusive, but the skin lesions of this cat resolved after 2 months supplement with oral PCSO-524® and external parasitic treatment with oral f vluralaner (Bravecto®, MSD).
In conclusion, oral PCSO-524® (Antinol®, Vetz Petz), could be considered as an anti-inflammation and skin barrier support when the cats could not be treated with potent anti-inflammatory medications such as corticosteroid or cyclosporine. The underlying causes of pruritic skin lesions should be corrected in order to manage feline pruritic skin diseases.
Effect of PCSO-524® Supplement on Inflammation and Pain Control and Its Safety for Orthopedic Surgery in Pregnant Cats
Authors:
Bone fracture is common in stray cats. It can cause severe pain and requires surgical treatment.
Use of non-steroidal anti-inflammatory drugs (NSAIDs) or opioid drugs is common for control of pain from bone fracture. However, adverse effects are frequently reported for NSAIDs and opioid use.
Objective of this study is to evaluate anti-inflammatory and pain-relieving effects and safety of PCSO-524® (Antinol®) for bone surgery in pregnant cats.
The Trial Treatment of Feline Osteoarthritis in an Eleven-Year-Old Cat
Authors:
A domestic short hair cat aged 11 years was taken to the hospital due to shaking and weakened hind legs. The cat could not perform high jump for 1 month.
Preliminary diagnosis included early stage of osteoarthritis of left hip and capsulitis.
Pain killers, NSAIDs and gabapentin, were administered but the response was not satisfied. Therefore, multimodal treatment program was initiated. Physical therapy using electrical stimulation and laser beam class 4 in conjunction with PCSO-524® were used. Measurement of joint movement angle (active range of motion; active ROM) in 2 dimensions using Kinovea program was conducted for follow up.
The study found increased active ROM and decreased lameness score after the treatment.
The owner described that the cat showed less isolation behavior and was able to perform vertical jump again. Overall quality of the cat’s life was improved.
Use of PCSO-524® (Antinol)® for treatment of Obsessive-Compulsive Disorders (OCD) in Domestic Short Hair Cat
Authors:
A 3 years old domestic short hair cat had shown behavioral disorder after castration 4 months ago.
The clinical signs were consistent with obsessive-compulsive disorders (OCD).
Pathological examination found edema of epidermis andinfiltration of mature mast cells in hair follicle. Treatment with PCSO-524® (Antinol)® for 180 days had shown that the misbehavior was improved due to decreased pain and skin inflammation. Healthier coat and skin appearance was noticed after 30 consecutive days of PCSO-524® (Antinol®) intake. Pathological follow-up showed less inflammation of epidermis and decreased mast cells infiltration.
It was shown that PCSO-524® (Antinol®) could reduce pain and inflammation that caused anxiety and consequently OCD in cats. Additional effects included antihistamine, antiallergy, and skin neurishing.
Updated Study Topics
New researches and publications related to PCSO-524® and its result in clnical test submitted by veterinarians on the global conferences every year and the data keeps growing with more studies conducted
