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Treatment of Severe Hind Limb Paresis and Posterior Paresis Caused by Traumatic Myelopathy in Cats Using PSCO-524® (Antinol®) and Physical Therapy
Authors:
A 2 years old domestic short hair cat weighted 3.55 kilograms was referred to Kasetsart University Veterinary Hospital for severe hind limb paresis with loss of sensory function. The onset of symptoms was observed a week ago after the cat returned from missing. Radiographic examination did not show any vertebral disorders. Magnetic Resonance Imaging (MRI) examination found accumulation of fluid in spinal cord at T10-T12 level, which indicated spinal cord injury. Traumatic myelopathy was diagnosed.
The paresis was grade 5 so PSCO-524® (Antinol®) 1 capsule per day was prescribed. After a week of the treatment, the cat was able to control urination and voluntary motor function of the hind limbs.
However, the sensory system malfunction remained. Spinal walk, walking with the hind limbs when sensation loss was observed after physical therapy was concurrently provided for 3 weeks.
Efficacy of Oral PCSO-524®
as an Anti-Inflammatory Medicationin a Persian Cat with Pruritic Skin Disease
Authors:
This is a case report of a Persian cat with severe pruritus, which was not improved by topical external parasitic treatment, food trial and 2 months treatment with oral cyclosporine at the dose 5mg/kg. The cat developed corneal ulcer after the long-term treatment with oral cyclosporine.
PCSO-524® (Antinol® Vetz Petz, New Zealand) was replaced cyclosporine as an anti-inflammation treatment and also was considered as a skin barrier support.
The cause of pruritic in this case report was still inconclusive, but the skin lesions of this cat resolved after 2 months supplement with oral PCSO-524® and external parasitic treatment with oral f vluralaner (Bravecto®, MSD).
In conclusion, oral PCSO-524® (Antinol®, Vetz Petz), could be considered as an anti-inflammation and skin barrier support when the cats could not be treated with potent anti-inflammatory medications such as corticosteroid or cyclosporine. The underlying causes of pruritic skin lesions should be corrected in order to manage feline pruritic skin diseases.
Effect of PCSO-524® Supplement on Inflammation and Pain Control and Its Safety for Orthopedic Surgery in Pregnant Cats
Authors:
Bone fracture is common in stray cats. It can cause severe pain and requires surgical treatment.
Use of non-steroidal anti-inflammatory drugs (NSAIDs) or opioid drugs is common for control of pain from bone fracture. However, adverse effects are frequently reported for NSAIDs and opioid use.
Objective of this study is to evaluate anti-inflammatory and pain-relieving effects and safety of PCSO-524® (Antinol®) for bone surgery in pregnant cats.
Use of PCSO-524® Combined with Surgical Treatment of Patellar luxation in Dogs
Authors:
Five dogs with bilateral patellar luxation were presented at the Small Animal Hospital of Faculty of Veterinary Medicine, Chulalongkorn University.
Four dogs had grade 2, 3, and 4 medial patellar luxation in 3, 3, and 2 stifle joints, respectively. One dog had grade 3 bilateral lateral patellar luxation that had recurrent patellar luxation of left stifle joint for 6 months after previous surgery. All dogs had surgical treatment to re-align and stabilize extensor mechanism in the normal position.
The dogs received anti-inflammatory drug and PCSO-524® in combination with rehabilitation to restore normal limb function and muscle mass postoperatively. All dogs achieved good outcomes when compared with pre-operation. Range of motion was normal in all dogs and the patellae were in the normal position.
However, one stifle with previous reluxation and severe osteoarthritis had slightly crepitation when flexed and extended the stifle joint. Patellar luxation causes abnormal wear of the patella and trochlear ridges leading to lameness, muscle pain, and osteoarthritis.
The treatment focuses on stabilization of the stifle joint and restore limb function. Surgical treatment is recommended in most cases. Rehabilitation provides strengthen muscle, improves normal joint function, enhanceslimb function, and prevents complications.
Despite successful treatment for correcting patellar luxation, osteoarthritis remains occurrence in most cases.
Therefore, use of anti-inflammatory supplement such as PCSO-524® is important for long-term management with less side effect and safety for long-term use when compared with non-steroidal anti-inflammatory drugs.
Efficacy of PCSO-524® and prednisolone combination treatment for neck pain in Chihuahua dog with Chiari-like malformation and syringomyelia
Authors:
A 18-month-old male intact chihuahua presented with recurrent neck pain within 3 months after stop using prednisolone.
Upon physical and neurological examination, dog displayed pain and neck stiffness without neurological deficits. Radiographic findings of cervical spine was normal.
The dog was treated with prednisolone to relieve pain and inflammation and showed improvement of clinical signs. However, the recurrence occurred in 7 months with more severity. Magnetic resonance
imaging (MRI) demonstrated Chiari-like malformation and syringomyelia at C2-C4 and C7-T1 region.
PCSO-524® (VetzPetz Antinol®) was administered in combination with prednisolone and gabapentin. The clinical signs improved in 2 weeks so prednisolone was gradually reduced until discontinued but dose of PCSO-524® remained constantly. The dog was able to recover from neck pain and continued life activities as normal.
Long-term supplement of PCSO-524® (VetzPetz Antinol®) was effective for reducing inflammation of spinal cord in dog suffered from neck pain caused by syringomyelia.
Use of PCSO-524® for Treatment of Spine Fracture in Conjunction with Pedicle Screw-Rod Fixation (PSRF)
Authors:
An intact male mixed breed dog aged 2 years engaged in a fight with several dogs resulting in disable of hind limbs and loss control of elimination. Physical and radiographic examination showed fracture and luxation of the 7th lumbar vertebrae. Spinal cord injury (SCI) was also found and the fracture was identified as the cause. The spinal cord trauma could occur since the incident and was left for more than 2 weeks.
Pedicle screw-rod fixation (PSRF) was operated to fix the vertebral column. After the second operation, it was suspected that there was remain of inflammatory cytokines that probably increased after the operation. Anti-inflammatory medication for prohibition of inflammatory cytokines synthesis was essential but its adverse effect must be concerned. The study therefore used holistic treatment including PSRF, non-steroidal drug and PCSO-524® anti-inflammatory extract, in conjunction with physical therapy.
Follow-up examination on neurological system, walking, and urinary system showed promising result. The neurological system was restored, and adverse effect of long-term use had not been found.
The Trial Treatment of Feline Osteoarthritis in an Eleven-Year-Old Cat
Authors:
A domestic short hair cat aged 11 years was taken to the hospital due to shaking and weakened hind legs. The cat could not perform high jump for 1 month.
Preliminary diagnosis included early stage of osteoarthritis of left hip and capsulitis.
Pain killers, NSAIDs and gabapentin, were administered but the response was not satisfied. Therefore, multimodal treatment program was initiated. Physical therapy using electrical stimulation and laser beam class 4 in conjunction with PCSO-524® were used. Measurement of joint movement angle (active range of motion; active ROM) in 2 dimensions using Kinovea program was conducted for follow up.
The study found increased active ROM and decreased lameness score after the treatment.
The owner described that the cat showed less isolation behavior and was able to perform vertical jump again. Overall quality of the cat’s life was improved.
Use of PCSO-524® (Antinol)® for treatment of Obsessive-Compulsive Disorders (OCD) in Domestic Short Hair Cat
Authors:
A 3 years old domestic short hair cat had shown behavioral disorder after castration 4 months ago.
The clinical signs were consistent with obsessive-compulsive disorders (OCD).
Pathological examination found edema of epidermis andinfiltration of mature mast cells in hair follicle. Treatment with PCSO-524® (Antinol)® for 180 days had shown that the misbehavior was improved due to decreased pain and skin inflammation. Healthier coat and skin appearance was noticed after 30 consecutive days of PCSO-524® (Antinol®) intake. Pathological follow-up showed less inflammation of epidermis and decreased mast cells infiltration.
It was shown that PCSO-524® (Antinol®) could reduce pain and inflammation that caused anxiety and consequently OCD in cats. Additional effects included antihistamine, antiallergy, and skin neurishing.
PCSO-524® Report Clinical Results of Nineteen Dogs with Tracheal Collapse that received PCSO-524®, a Lipid Extract of the New Zealand Green-Lipped Mussel (Perna canaliculus)
Authors:
Case: Nineteen dogs presented with cough and diagnosed with tracheal collapse based on inspiration / expiration chest radiography between December 2013 and April 2015.
Tracheal collapse is a respiratory disorder characterized by the decrease of supporting force of the tracheal cartilage which results in abnormal dilating and flattening of the trachea. It is common in small-breed dogs and brachycephalic dogs. Tracheal collapse results from a number of causes including genetic factors, obesity, tracheal cartilage degeneration, chronic bronchitis, respiratory infection, and cardiovascular dysfunction. The combination with these causes worsens symptoms.
Comprehensive management is required such as medical treatment as well as surgical treatment at the time of progression.
This report summarize positive effects of PCSO-524® (Antinol®), a supplement product which includes anti-inflammatory fatty acids extracted from Perna canaliculus, another kind of green-lipped mussels, given to dogs with tracheal collapse.
Use of PCSO-524® (Antinol®) for Treatment of Nervous Disorder Caused by Car Accident and Hip Osteoarthritis in Geriatric Cats
Authors:
Male castrated Persian cat aged 12 years was injured at the rear body in an automobile accident causing paralysis of the hind limbs.
X-ray examination found luxation of both pelvic joints and osteoarthritis of hip joint. Nervous disorder of the hind limbs was diagnosed from the absence of the motor and deep pain sensory impulse. MRI examination found no spinal cord damage.
The treatment included electrical stimulation at the hind limb muscle in combination with long-term administration of PCSO-524® (Antinol®).
The hind limbs were functional normally at the end of the treatment and blood chemistry examination at 32 weeks after the treatment showed normal liver and kidney indicators.
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New researches and publications related to PCSO-524® and its result in clnical test submitted by veterinarians on the global conferences every year and the data keeps growing with more studies conducted
